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胎儿肥大细胞介导产后过敏反应
作者:小柯机器人 发布时间:2020/10/31 21:49:46

近日,新加坡国立大学Florent Ginhoux、Ashley L. St. John等研究人员合作发现,胎儿肥大细胞介导取决于母亲IgE的产后过敏反应。相关论文于2020年10月29日在线发表在《科学》杂志上。

研究人员显示,人类和小鼠的胎儿肥大细胞(MC)通过妊娠来实现表型成熟,并且可以通过母体IgE致敏。IgE跨越胎盘取决于胎儿的新生儿Fc受体(FcRN),并使得胎儿MC变得敏感。被动和主动的产前致敏都赋予了过敏原敏感性,从而导致第一次接触过敏原后的产后皮肤和气道发炎。
 
研究人员报告了在胎儿发育中MC的作用,并证明胎儿MC可能有助于过敏性疾病的抗原特异性垂直传播。
 
据了解,MC是变态反应中的中枢效应细胞,通常由IgE介导。过敏通常始于幼年,胎儿中可检测到MC和IgE。然而,目前尚不清楚胎儿MC是否在功能上能够胜任IgE介导的激活以及胎儿IgE的起源。
 
附:英文原文

Title: Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE

Author: Rasha Msallam, Jozef Balla, Abhay P. S. Rathore, Hassen Kared, Benoit Malleret, Wilfried A. A. Saron, Zhaoyuan Liu, Jing Wen Hang, Charles Antoine Dutertre, Anis Larbi, Jerry K. Y. Chan, Ashley L. St. John, Florent Ginhoux

Issue&Volume: 2020/10/29

Abstract: Mast cells (MCs) are central effector cells in allergic reactions, often mediated by IgE. Allergies commonly start at an early age, and both MCs and IgE are detectable in fetuses. However, whether fetal MCs are functionally competent to IgE-mediated activation and the origin of fetal IgE are presently unknown. We show that human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by maternal IgE. IgE crossed the placenta, dependent on the fetal neonatal Fc-receptor (FcRN), and sensitized fetal MCs for allergen-specific degranulation. Both passive and active prenatal sensitization conferred allergen sensitivity, resulting in postnatal skin and airway inflammation following the first allergen encounter. We report a role for MCs within the developing fetus and demonstrate that fetal MCs may contribute to antigen-specific vertical transmission of allergic disease.

DOI: 10.1126/science.aba0864

Source: https://science.sciencemag.org/content/early/2020/10/28/science.aba0864

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037